At last follow-up, all patients had retained their gonads, all have female gender identity with no reported gender dysphoria, and no progression of androgenization.Conclusions
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Three patients were initiated with estrogen replacement to promote desired breast development. Three patients have been receiving hormonal suppression for 1.4 years (1.1–1.9 years) without side effects or complication. One patient presented as an infant, and is being monitored until Tanner stage 2 and/or serum hormonal evidence to initiate hormonal suppression. All patients were evaluated in a coordinated multidisciplinary clinic. Initial evaluation by DSD team was at a mean age of 6.6 years (3 weeks–16 years). We excluded those with complete gonadal dysgenesis or complete androgen insensitivity.ResultsFour patients met inclusion criteria. Patients on hormonal suppression had at least 6 months of follow-up from initiation.
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Inclusion criteria were 46,XY DSD, female sex of rearing, risk of androgenization at puberty, and plan for hormonal suppression at puberty. We performed a retrospective review of the past 10 years of DSD patients treated by a multidisciplinary program. PurposeWe aim to report outcomes and safety with hormonal suppression to facilitate gonadal preservation in a select group of patients with 46,XY differences in sex development (DSD) who are raised and identify as female yet have diagnoses with potential for androgenization at puberty.Methods